学术报告:Nanotechnology Approaches to Biological Heterogeneity and Cellular Therapies

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报告题目:Nanotechnology Approaches to Biological Heterogeneity and Cellular Therapies

报 告 人:Paul S. Weiss

报告时间:2017年10月18日(星期三)上午10:30

报告地点:张江园区办公楼大报告厅

报告人简介:

Paul S. Weiss holds a UC Presidential Chair and is a distinguished professor of chemistry & biochemistry and of materials science & engineering atUCLA. He received his S.B. and S.M. degrees in chemistry from MIT in 1980 and his Ph.D. in chemistry from the University of California at Berkeley in 1986. He was a postdoctoral member of technical staff at Bell Laboratories from 1986-88 and a visiting scientist at IBM Almaden Research Center from 1988-89. He served as the director of the California NanoSystems Institute and held the Fred Kavli Chair in NanoSystems Sciences at UCLA from 2009-14. Before coming to UCLA, he was adistinguished professor of chemistry and physicsat the Pennsylvania State University, where he began his academic career in 1989. His interdisciplinary research groupincludes chemists, physicists, biologists, materials scientists, mathematicians, electrical and mechanical engineers, computer scientists, clinicians, and physician scientists.They focus on the ultimate limits of miniatu­rization, exploring the atomic-scale chemical, physical, optical, mechanical, and electronic properties of surfaces, interfaces, and supramolecular assemblies. Theydevelop new techniques to expand the applicability and chemical specificity of scanning probe microscopies. They apply these and other tools to study self- and directed assembly, and molecular and nanoscale devices. They advance nanofabrication down to ever smaller scales and greater chemical specificity to operate and to test functional molecular assemblies, and to connect these to the biological and chemical worlds. Two major themes in his laboratory are cooperativity in functional molecules and single-molecule/assembly biological structural and functional measurements. He has written over 300publications, holds over 30 patents, and has given over 700 invited, plenary, keynote, and named lectures.

Weiss has been awarded a National Science Foundation (NSF) Presidential Young Investigator Award (1991-96), the Scanning Microscopy International Presidential Scholarship (1994), the B. F. Goodrich Collegiate Inventors Award (1994), an Alfred P. Sloan Foundation Fellowship (1995-97), the American Chemical Society (ACS) Nobel Laureate Signature Award for Graduate Education in Chemistry (1996), a John Simon Guggenheim Memorial Foundation Fellowship (1997), a NSF Creativity Award (1997-99), the ACSAward in Colloid and Surface Chemistry (2015), and the ACS Southern California Section Tolman Medal (2017), among others. He was elected a fellow of: the American Association for the Advancement of Science (2000), the American Physical Society (2002), the American Vacuum Society (2007), the ACS (2010), the American Academy of Arts and Sciences (2014), the American Institute for Medical and Biological Engineering (2016), the Canadian Academy of Engineering (2017), and an honorary fellow of the Chinese Chemical Society (2010).He was also elected a senior member of the IEEE (2009).He received Penn State’s University Teaching Award from the Schreyer Honors College (2004), was named a nanofabrication fellow at Penn State (2005), and won the Alpha Chi Sigma Outstanding Professor Award (2007). He was a visiting professor at the University of Washington, Department of Molecular Biotechnology (1996-97) and Kyoto University, Electronic Science and Engineering Department and Venture Business Laboratory (1998 and 2000), anda distinguished visiting professor at the Kavli Nanoscience Institute and the Joint Center for Artificial Photosynthesis at Caltech (2015).He is a visiting scholar at the Kavli Institute for Bionano Science & Technology and the Wyss Institute for Biologically Inspired Engineeringat Harvard University (2015-18). He is the Institut National de la RechercheScientifique (INRS)Chaired'excellenceJacques­Beaulieu at the Centre for Energy, Materials and Telecommunications (2016-17).He was a Fulbright Specialist for the Czech Republic (2017). Weiss was a member of the U.S. National Committee to the International Union of Pure and Applied Chemistry (2000-05).He has been the technical co-chair of the Foundations of Nanoscience Meetings, thematic chair of the Spring 2009 and Fall 2018 ACS National Meetings. He was the senior editor of IEEE Electron Device Letters for molecular and organic electronics (2005-07), and is the founding editor-in-chief of ACS Nano(2007-). At ACS Nano, he won the Association of American Publishers, Professional Scholarly Publishing PROSE Award for 2008, Best New Journal in Science, Technology, and Medicine, and ISI’s Rising Star Award a record ten times.

 

报告简介:

The great promise of single-molecule/assembly measurements is to understand how critical variations in structure, conformation, and environment relate to and control function. New approaches to sensing, imaging, and analysis are keys to elucidating these associations. I will discuss current and upcoming advances and will pose the challenges that lie ahead in creating, developing, and applying new tools for biology and medicine. These advances include using biomolecular recognition in sensor arrays to probe dynamic chemistry in the brain and microbiome systems. It also includes fusing spectroscopic imaging modalities and freeing up bandwidth in measurements to record simultaneous data streams and to expand our dynamic range. Recent advances in sparsity and compressive sensing can be applied both to new analysis methods and to directing measurements so as to assemble and to converge structural and functional information. Early examples will be discussed.

 

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